| David Carradine | ...Kwai Chang Caine (59 episodes, 1972-1975) |
| David Carradine | ...Caine |
| Barry Sullivan | ...Dillon |
| Radames Pera | ...Young Caine / ... (44 episodes, 1972-1975) |
| Keye Luke | ...Master Po / ... (44 episodes, 1972-1975) |
| Albert Salmi | ...Raif |
| Philip Ahn | ...Master Kan (37 episodes, 1972-1975) |
| Wayne Maunder | ...McKay |
| Benson Fong | ...Han Fei |
| James Hong | ...Chun Yen / ... (8 episodes, 1973-1975) |
| Richard Loo | ...Master Sun / ... (7 episodes, 1972-1974) |
| Richard Loo | ...Master Sun |
| James Weatherill | ...Deputy / ... (7 episodes, 1972-1975) |
| Keye Luke | ...Master Po |
| Philip Ahn | ...Master Kan |
| Victor Sen Yung | ...Tamo / ... (6 episodes, 1973-1974) |
| Tad Horino | ...Chemist / ... (6 episodes, 1973-1975) |
| Victor Sen Yung | ...Chuen |
| Tim McIntire | ...Danny Caine / ... (5 episodes, 1973-1975) |
| Robert Ito | ...Fong |
| Yuki Shimoda | ...Shun Low / ... (5 episodes, 1973-1974) |
| James Hong | ...Hsiang |
| John Fujioka | ...Cook / ... (5 episodes, 1973-1975) |
| Radames Pera | ...Young Caine |
| Leslie Nielsen | ...Vincent Corbino (4 episodes, 1975) |
| Roy Jenson | ...Fuller |
| John Blyth Barrymore | ...Zeke Caine (4 episodes, 1975) |
| John Leoning | ...Master Teh |
| David Chow | ...Little Monk |
| Ted Gehring | ...Fuller / ... (4 episodes, 1974-1975) |
| Tim Haldeman | ...First Gunfighter / ... (4 episodes, 1972-1975) |
| Keith Carradine | ...Middle Caine (uncredited) |
| Bill McLean | ...Bartender (uncredited) |
| Khigh Dhiegh | ...Warlord Sing / ... (4 episodes, 1973-1974) |
| Hidy Ochiai | ...(uncredited) |
| Clyde Kusatsu | ...Han Su Lok & Lama Kushog / ... (4 episodes, 1973-1975) |
| Frank Michael Liu | ...Huo / ... (4 episodes, 1973-1975) |
| Clay Tanner | ...Barr / ... (4 episodes, 1973-1974) |
| John Carradine | ...Rev. Serenity Johnson (3 episodes, 1972-1975) |
| John Vernon | ...Gen. Cantrell / ... (3 episodes, 1974-1975) |
| Benson Fong | ...Li Yu / ... (3 episodes, 1973-1974) |
| Ned Romero | ...Lame Dog / ... (3 episodes, 1974-1975) |
| Kenneth O'Brien | ...Arlo / ... (3 episodes, 1973-1974) |
| Soon-Tek Oh | ...Chen Yi / ... (3 episodes, 1973-1974) |
| Richard Narita | ...Kang Li / ... (3 episodes, 1974) |
| Paul Harper | ...Amos / ... (3 episodes, 1972-1974) |
| Beulah Quo | ...Madame Chun / ... (3 episodes, 1973-1975) |
| Dale Ishimoto | ...Chinese Sergeant / ... (3 episodes, 1973-1975) |
| Bill McLean | ...Bartender / ... (3 episodes, 1972-1973) |
| Bob Bralver | ...Crowder / ... (3 episodes, 1973) |
| Steven Chambers | ...Comancheros / ... (3 episodes, 1973) |
| Hal Williams | ...Caleb Brown (2 episodes, 1973-1975) |
| Albert Salmi | ...Reuben Branch / ... (2 episodes, 1973-1974) |
| Morgan Woodward | ...Adversary / ... (2 episodes, 1973-1974) |
| James Shigeta | ...Col. Lin Pei / ... (2 episodes, 1974-1975) |
| Stefan Gierasch | ...Kai Tong / ... (2 episodes, 1974) |
| Barbara Hershey | ...Nan Chi (2 episodes, 1974) |
| Lois Nettleton | ...Delonia Cartell (2 episodes, 1975) |
| L.Q. Jones | ...Major Bealson / ... (2 episodes, 1973-1975) |
| Dana Elcar | ...Noah Jones / ... (2 episodes, 1973) |
| Shelly Novack | ...Bascomb / ... (2 episodes, 1973-1974) |
| Michael Pataki | ...Buskirk (2 episodes, 1974) |
| A Martinez | ...Slade / ... (2 episodes, 1974-1975) |
| Jim Davis | ...Sheriff Grogan / ... (2 episodes, 1973) |
| Robert Ridgely | ...(2 episodes, 1974) |
| Nancy Kwan | ...Mayli Ho (2 episodes, 1974) |
| Brian Tochi | ...Ho Fong / ... (2 episodes, 1973-1974) |
| Mae Mercer | ...Elizabeth Brown (2 episodes, 1973-1975) |
| John Lupton | ...McCord (2 episodes, 1975) |
| Ed Bakey | ...Bloom (2 episodes, 1974) |
| Valentin de Vargas | ...Mendoza (2 episodes, 1975) |
| Larry J. Blake | ...Dave Etling / ... (2 episodes, 1973-1974) |
| Ivan Naranjo | ...Tall Pot (2 episodes, 1974) |
| Bill Fletcher | ...Father / ... (2 episodes, 1973-1975) |
| Julio Medina | ...Father Salazar / ... (2 episodes, 1973-1975) |
| George Spell | ...Daniel Brown / ... (2 episodes, 1973-1975) |
| Jeanne Joe | ...Lu Tien / ... (2 episodes, 1974-1975) |
| Robert F. Hoy | ...Curry McCoy / ... (2 episodes, 1972-1973) |
| Don Keefer | ...Station Keeper / ... (2 episodes, 1974-1975) |
| Sam Hiona | ...Hake Tao (2 episodes, 1974) |
| Kay E. Kuter | ...Marshal / ... (2 episodes, 1974-1975) |
| Stephen Manley | ...Boy Caine (2 episodes, 1975) |
| Frances Fong | ...Nurse / ... (2 episodes, 1974-1975) |
| Bill Saito | ...Murderer / ... (2 episodes, 1974-1975) |
| Don Hanmer | ...Jaffe (2 episodes, 1974) |
| Ta-Ronce Allen | ...Juliet Brown (2 episodes, 1973-1975) |
| John War Eagle | ...Indian Chief / ... (2 episodes, 1973-1974) |
| Kam Yuen | ...First Master / ... (2 episodes, 1973-1974) |
| Arthur Song | ...Old Man / ... (2 episodes, 1974-1975) |
| Donald Eiber | ...Elvis / ... (2 episodes, 1972-1973) |
| David Huddleston | ...Nathaniel / ... (2 episodes, 1973-1975) |
| John Anderson | ...Benjamin Dundee / ... (2 episodes, 1973-1974) |
| Michael Greene | ...Aztec Priest / ... (2 episodes, 1973-1974) |
| Denver Pyle | ...Dr. Colton / ... (2 episodes, 1973-1974) |
| Scott Hylands | ...Randy / ... (2 episodes, 1973) |
| Bruce Carradine | ...Capt. Starbuck / ... (2 episodes, 1974-1975) |
| Clare Nono | ...Cinnamon / ... (2 episodes, 1974-1975) |
| Ken Swofford | ...Max / ... (2 episodes, 1974) |
| Adrienne Marden | ...Coralee (2 episodes, 1972-1974) |
| Howard Duff | ...Mr. Jenkins / ... (2 episodes, 1974) |
| William Mims | ...Jezdale / ... (2 episodes, 1973-1975) |
| Byron Mabe | ...Cranch / ... (2 episodes, 1973-1975) |
| Alex Henteloff | ...Abner Tutt / ... (2 episodes, 1973-1974) |
| Kenji Shibuya | ...Ah Quong / ... (2 episodes, 1973-1974) |
| Dana Lee | ...Lieutenant (2 episodes, 1974) |
| Charles Bail | ...First Tough / ... (2 episodes, 1972-1975) |
| Robert Ito | ...Blacksmith / ... (2 episodes, 1973-1974) |
| Richard Lee-Sung | ...Fourth Master / ... (2 episodes, 1974-1975) |
| Ivy Bethune | ...Jenny McCoy / ... (2 episodes, 1972-1975) |
| R.L. Armstrong | ...Clancy Pratt / ... (2 episodes, 1973-1975) |
| Tommy Lee | ...Apothecary / ... (2 episodes, 1974-1975) |
| Ray Ballard | ...Announcer / ... (2 episodes, 1974-1975) |
| Keith Carradine | ...Caine as teenager / ... (2 episodes, 1972-1973) |
| Jerry Fujikawa | ...Poor Man / ... (2 episodes, 1973-1975) |
| Erik Cord | ...Cowboy / ... (2 episodes, 1973-1974) |
| Fred Lerner | ...Blaney (2 episodes, 1973-1974) |
| Warren Vanders | ...Clifford Tate / ... (2 episodes, 1973-1974) |
| Carey Wong | ...First Pupil / ... (2 episodes, 1973-1974) |
| Anthony Zerbe | ...Paul Klempt / ... (2 episodes, 1973-1974) |
| Chuck Hayward | ...Drifter / ... (2 episodes, 1973) |
| Jesse Dizon | ...Apprentice / ... (2 episodes, 1974-1975) |
| Tony Epper | ...Dirk / ... (2 episodes, 1974-1975) |
| Raymond Chao | ...Second Pupil / ... (2 episodes, 1974) |
| George Chiang | ...Shun Low's Sentry (2 episodes, 1974) |